Medical

March 8th, 2010
by cirrex

The scientific literature recognizes Cirrex’s award-winning optical technology as having enabled in vivo characterization of tissues and pharmaceutical agents using Raman spectroscopy. Implemented at a fiber optic tip, this powerful technique uses laser light to determine chemical makeup deep within patients and laboratory animals.  The nondestructive real-time analysis reveals drug-tissue interactions, dynamic responses of diseased tissue to therapies, pharmaceutical activity and related physiological changes induced by drug delivery, subtle disease states, tumor boundaries, composition of atherosclerotic plaques, and many other biological and biochemical parameters relevant to pharmaceutical research and clinical procedures.

Using integrated optics, we compressed the functionality of a cigar-box-size optical system into a package fitting in the tips of surgical needles and catheters while achieving superior optical performance.  The resulting devices realize disposable economics when deployed in volume applications, as they are engineered for mass production.

Beyond the laser-Raman technique, our optics empower florescence, near infrared, and other analytical instrumentation systems with heightened sensitivity and new capabilities. Light management techniques overcome absorption and scattering in optically challenging biological materials and other analytes and resolve tissue compositions in three dimensions. A properly outfitted probe can discriminate and assay a tissue structure buried a standoff distance from the probe while avoiding interference from intervening and surrounding tissues. Products incorporating the technology are known under the brands “Visionex”, “Enviva”, “Gaser Light Management System” and, “In-The-Tip Filters”.

Representative Medical Publications

  • Buschman H, Marple E, Wach M, Bennett B, Schut T, Bruining H, Bruschke A, van der Laarse A, Puppels G. (August 2000) “ In vivodetermination of the molecular composition of artery wall by intravascular Raman spectroscopy.” Analytical Chemistry, Vol. 72, No. 16, 3771-3775.
  • Shim M, Wilson B, Marple E, Wach M. (June 1999) “A study of fiber optic probes for in vivo medical Raman spectroscopy.” Applied Spectroscopy, Vol. 53, No. 6, 619-627.
  • Buschman H, Schut T, Bruining H, Marple E, Wach M, Bennett R, Bruschke A, van der Laarse A, Puppels G. (August/September 1999) “ In vivo determination of the molecular composition of artery wall by intravascular Raman spectroscopy.” European Conference on the Spectroscopy of Biological Molecules, Enschede, The Netherlands.
  • Buschman H, Marple E, Wach M, van der Laarse A, Pupples G. (August/September 1999) “Histopathological assessment of atherosclerotic plaques by optical fiber-based Raman spectroscopy.” 21st Annual Congress of the European Society of Cardiology, Barcelona, Spain.
  • Buschman H, Marple E, Wach M, van der Laarse A, Pupples G. (August/September 1999) “Histopathological assessment of atherosclerotic plaques by optical fiber-based Raman spectroscopy.” European Heart Journal, Abstr, Suppl, 68.
  • Buschman H, Romer T, Wach M, Marple E, van der Laarse A, Bruschke A, Puppels G. (1999) “Human coronary atherosclerosis studied in vitro by catheter-based transluminal Raman spectroscopy.” SPIE, Vol. 3608, 12-17.
  • Buschman H, Romer T, Wach M, Marple E, van der Laarse A, Bruschke A, Puppels G. (June 1999) “Human coronary atherosclerosis studied in vitro by catheter-based transluminal Raman spectroscopy.” International Biomedical Optics Symposium (BiOS’99), San Jose, CA.
  • Puppels G, Van Aken T, Wolthuis R, Caspers P, Schut T, Bruining H, Romer T, Buschman H, Wach M, Robinson J. (1998) “ In vivo tissue characterization by Raman spectroscopy.” SPIE, Vol. 3257, 78-83.
  • Puppels G, Van Aken T, Wolthuis R, Caspers P, Schut T, Bruining H, Romer T, Buschman H, Wach M, Robinson J. (January 1998) “ In vivo tissue characterization by Raman spectroscopy.” International Biomedical Optics Symposium (BiOS’98), San Jose, CA.
  • Shim M, Wilson B, Marple E, Wach M. (1999) “Evaluation of fiber optic probes for in vivo Raman spectroscopy.” Proceedings of Infrared Spectroscopy: New Tool in Medicine, SPIE, Vol. 3257, 208-217.
  • Shim M, Wilson B, Marple E, Wach M. (January 1998) “Evaluation of fiber optic probes for in vivo Raman spectroscopy.” International Biomedical Optics Symposium (BiOS’98), San Jose, CA.
  • Shim M, Wilson B, Marple E, Wach, M. (October 1997) “Fiber optic light management for Raman analysis of absorbing and elastic scattering media: biological tissues.” 24th Annual Conference of the Federation of Analytical Chemistry and Spectroscopy (FACSS’97), Providence, RI.